Key result
Low-dose aspirin did not reduce the incidence of hypertensive disorders of pregnancy compared to placebo in healthy, nulliparous women (OR 1.64; 95% CI 0.59-4.6).
Why the study?
Does low-dose aspirin prevent hypertensive disorders of pregnancy in relatively low-risk, healthy, nulliparous women?
RCT (n=118)
Double-blind
Randomized
Does low-dose aspirin prevent hypertensive disorders of pregnancy in relatively low-risk, healthy, nulliparous women?
Odds Ratio: 1.64 (95% CI 0.59–4.6)
Low-dose aspirin (75 mg) does not appear to prevent hypertensive disorders of pregnancy in healthy, low-risk nulliparous women, though the study was underpowered.
Low-dose aspirin confers no preventive benefit in healthy nulliparous women; challenges routine use and directs future trials to higher-risk groups.
Objective: To assess the role of low-dose aspirin in the prevention of hypertensive disorders of pregnancy in relatively low-risk, healthy, nulliparous women.Method: Randomized, double-blind, placebo-controlled trial involving 118 healthy, nulliparous women with a high hemoglobin concentration in the second trimester. Participants took either 75 mg aspirin or placebo from 18 weeks until delivery.Main Outcome Measures: Patient characteristics. Pregnancy outcome including incidence of hypertensive disorders of pregnancy.Results: There was no difference in pregnancy outcome between the two groups. Specifically, the odds ratio for the incidence of hypertensive disorders of pregnancy was 1.64 (95% CI 0.59–4.6). The overall incidence of emergency caesarean section in the two groups was similar. The odds ratio for delivery by emergency caesarean section in labor was 1.29 (95% CI 0.5–3.16). There was no difference in neonatal outcome in terms of admission rates to a neonatal intensive care unit and no difference in neonatal morbidity.Conclusion: The study involves too few subjects to show statistically significant differences in outcome measures and therefore invalidates firm conclusions, but low-dose aspirin does not appear to be of benefit in healthy, nulliparous women at relatively low risk of hypertensive disorders of pregnancy.
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Davies et al. (1995) conducted an RCT in Hypertensive disorders of pregnancy (n=118). Low-dose aspirin vs. Placebo was evaluated on Incidence of hypertensive disorders of pregnancy (OR 1.64, 95% CI 0.59-4.6). Low-dose aspirin did not reduce the incidence of hypertensive disorders of pregnancy compared to placebo in healthy, nulliparous women (OR 1.64; 95% CI 0.59-4.6).