Key result
Low-dose aspirin started prior to pregnancy did not significantly reduce the incidence of hypertensive pregnancy complications compared to placebo in IVF/ICSI patients (15.4% vs 18.2%; P=0.70).
Why the study?
Does low-dose aspirin reduce the incidence of hypertensive pregnancy complications in unselected IVF and ICSI patients?
RCT (n=487)
Double-blind
randomized
Does low-dose aspirin reduce the incidence of hypertensive pregnancy complications in unselected IVF and ICSI patients?
Absolute Event Rate: 15.4% vs 18.2%
p-value: p=0.70
Low-dose aspirin started prior to pregnancy and continued until delivery does not significantly reduce the incidence of hypertensive pregnancy complications in unselected IVF/ICSI patients.
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Low-dose aspirin does not reduce hypertensive complications in unselected IVF/ICSI; challenges prior hypotheses and leaves targeted use open for further study.
Haapsamo et al. (2010) conducted an RCT in IVF and ICSI (n=487). Low-dose aspirin vs. placebo was evaluated on incidence of hypertensive pregnancy complications (95% CI -17 to 11%, p=0.70). Low-dose aspirin started prior to pregnancy did not significantly reduce the incidence of hypertensive pregnancy complications compared to placebo in IVF/ICSI patients (15.4% vs 18.2%; P=0.70).
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