Key result
The distal segment of the third intracellular loop of the rat AT1A receptor plays a pivotal role in G protein coupling selectivity and transduction of the mitogenic signal of AngII.
The distal segment of the third intracellular loop of the rat AT1A receptor is crucial for G protein coupling selectivity and activation of mitogenic signaling pathways.
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No immediate clinical implications from rat AT1A study; leaves open receptor domain roles in human AngII signaling.
Conchon et al. (1997) studied this question. Chimeric AT1A receptors (alpha1B-AR, beta2-AR, AT2 replacements) vs. Wild type AT1A receptor was evaluated on Pharmacological and functional properties (inositol phosphate, cAMP, thymidine incorporation, internalization). The distal segment of the third intracellular loop of the rat AT1A receptor plays a pivotal role in G protein coupling selectivity and transduction of the mitogenic signal of AngII.
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