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September 1, 1996Journal of Biological ChemistryOpen Access

Intracellular Third Loop Domain of Angiotensin II Type-2 Receptor

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Population

Adult rat aortic vascular smooth muscle cells

Comparison

Synthetic intracellular third loop peptide of… vs Control peptide consisting of the same amino…

Design

Preclinical

Authors

WHWataru HayashidaMHMasatsugu HoriuchiVDVictor J. Dzau

Discussion

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Overview

AT2 receptor third loop suppresses VSMC proliferation; extends mechanistic insight but leaves open clinical translation.

Structured PICO

P
Population
Adult rat aortic vascular smooth muscle cells
I
Intervention
Synthetic intracellular third loop peptide of the AT2 receptor (AT2-3LP, 22 amino acids) delivered by cationic liposome-mediated transfection
C
Comparator
Control peptide consisting of the same amino acid composition in random sequence
O
Outcome
Serum-stimulated DNA synthesis, cell proliferation, and mitogen-activated protein kinase activitysurrogate

The intracellular third loop domain of the AT2 receptor mediates growth inhibition and alters mitogen-activated protein kinase activity via Gi and protein-phosphotyrosine phosphatase pathways in vascular smooth muscle cells.

Cite This Study

Hayashida et al. (1996) studied this question.

synapsesocial.com/papers/6a85b70137bcb8373dadb7achttps://doi.org/10.1074/jbc.271.36.21985
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.1993 · 716 citations
  2. 2Modulation of the delayed rectifier K+ current in neurons by an angiotensin II type 2 receptor fragment1995 · 133 citations
  3. 3Identification of a Domain in the Angiotensin II Type 1 Receptor Determining Gq Coupling by the Use of Receptor Chimeras1995 · 171 citations
  4. 4The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.1995 · 682 citations
  5. 5Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.1988 · 1,073 citations