Key result
In patients without connective tissue disorder or root pathology, aortic valve preservation was achieved in 100%, 86.2%, and 55% of those with mild, moderate, and severe aortic insufficiency.
Why the study?
The authors sought to determine risk factors for aortic valve replacement with or without root replacement during acute type A aortic dissection repair.
What are the risk factors for requiring aortic valve replacement during repair of acute type A aortic dissection?
Cohort (n=206)
No
What are the risk factors for requiring aortic valve replacement during repair of acute type A aortic dissection?
The vast majority of tricuspid aortic valves in patients without connective tissue disorder or aortic root pathology can be salvaged during acute type A aortic dissection repair.
Answers are grounded in this paper and cite their sources.
Supports valve preservation feasibility in selected acute type A dissection; leaves open durability and reintervention risk versus replacement.
BACKGROUND: We sought risk factors for replacement of the aortic valve with or without the root (AVR/root) in the setting of acute type A aortic dissection (ATAD) repair. METHODS: All ATAD repairs at our institution from January 2005 to June 2018 were reviewed. Baseline characteristics were recorded. For patients with aortic valve preservation, we documented the degree of aortic insufficiency (AI) postoperatively and on subsequent echocardiograms when available. Logistic regression was used to determine the association between preoperative characteristics and the odds ratio of AVR/root. RESULTS: 206 patients underwent repair of ATAD. Thirty-four were excluded for no documented AI grading. Forty-six underwent AVR/root during repair of the ATAD (including 40 root replacements). Of 126 that did not undergo AVR/root, 42 (33.33%) had follow-up echocardiograms at a median of 68 months postoperatively, 2 required reintervention for valve insufficiency. An increase in the degree of AI, bicuspid valve morphology, size of the aortic root, and connective tissue disorder was significantly associated with increased risk of AVR/root. Of 130 patients without connective tissue disorder, bicuspid aortic valve, aortic root aneurysm or intimal root tear, the rate of valve preservation was 65/65 (100%), 25/29 (86.2%), and 22/40 (55%) for those presenting with mild, moderate, and severe AI, respectively. CONCLUSION: The degree of preoperative AI, bicuspid valve morphology, size of the aortic root, and connective tissue disorder significantly correlate with the failure of aortic valve preservation in patients with ATAD. The vast majority of tricuspid valves in patients without connective tissue disorder or aortic root pathology can be salvaged.
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Thornhill et al. (2020) conducted a cohort in Acute type A aortic dissection (ATAD) (n=206). Preoperative risk factors (degree of aortic insufficiency, bicuspid valve, root size, connective tissue disorder) vs. Absence of these risk factors was evaluated on Replacement of the aortic valve with or without the root (AVR/root). In patients without connective tissue disorder or root pathology, aortic valve preservation was achieved in 100%, 86.2%, and 55% of those with mild, moderate, and severe aortic insufficiency.
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