September 1, 2008
Na diffusion dependent Ca handling in rabbit ventricular myocytes
Key result
In computational simulations of rabbit ventricular myocytes, a dramatic slowing of the Na diffusion coefficient or high colocalization of transporters was required to predict altered local Na effects.
Population
Rabbit ventricular myocyte computational model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Local Na effects on Ca handling require extreme diffusion slowing or colocalization in rabbit models; leaves open relevance to human myocytes.
Structured PICO
P
Population
Rabbit ventricular myocyte computational model
E
Exposure
Simulation of altered local intracellular Na concentration ([Na]i) gradients
O
Outcome
Effect of altered local [Na]i on Ca handlingsurrogate
Computational modeling suggests that slow Na diffusion or high colocalization of Na and Ca transporters is necessary to explain the effects of local intracellular Na gradients on Ca handling in ventricular myocytes.
Cite This Study
Grandi et al. (2008) studied this question. Computational modeling of Na diffusion was evaluated on Prediction of experimentally derived indirect effects of altered local intracellular Na on Ca handling. In computational simulations of rabbit ventricular myocytes, a dramatic slowing of the Na diffusion coefficient or high colocalization of transporters was required to predict altered local Na effects.