Key result
Higher systolic blood pressure reactivity to mental stress was associated with an increased number of small silent infarcts (r2=0.14; P=0.004) and greater severity of white matter hyperintensities.
Why the study?
Is stress-induced blood pressure reactivity associated with silent cerebrovascular disease on MRI in healthy older adults?
Population
67 nondemented, community-dwelling older adults free of major medical, neurological, or psychiatric disease
Design
Cross-sectional
Authors
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May signal cerebrovascular vulnerability to stress; leaves open whether reactivity modification improves outcomes in older adults.
Cross-Sectional (n=67)
Is stress-induced blood pressure reactivity associated with silent cerebrovascular disease on MRI in healthy older adults?
Effect estimate: r2=0.14
p-value: p=0.004
Exaggerated stress-induced blood pressure reactivity is associated with increased silent cerebrovascular disease on MRI in healthy older adults, independent of resting blood pressure.
Waldstein et al. (2004) conducted a cross-sectional in Silent cerebrovascular disease (n=67). Stress-induced blood pressure reactivity was evaluated on Small silent infarcts (≥3 mm) and white matter hyperintensities on MRI (r2=0.14, p=0.004). Higher systolic blood pressure reactivity to mental stress was associated with an increased number of small silent infarcts (r2=0.14; P=0.004) and greater severity of white matter hyperintensities.
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