Key result
Myozenin is a newly identified 32-kDa alpha-actinin- and gamma-filamin-binding Z line protein expressed predominantly in skeletal muscle, mapping to human chromosome 10q22.1-q22.2.
Population
Human skeletal muscle cDNA library
Design
Preclinical
Authors
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Myozenin identification as Z-line candidate gene warrants screening in unexplained myopathies; leaves open its pathogenic role pending human validation.
Myozenin is a newly identified skeletal muscle Z line protein that interacts with alpha-actinin and gamma-filamin, representing a potential candidate gene for neuromuscular disorders.
Takada et al. (2001) studied this question. Myozenin is a newly identified 32-kDa alpha-actinin- and gamma-filamin-binding Z line protein expressed predominantly in skeletal muscle, mapping to human chromosome 10q22.1-q22.2.
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