Review of mechanisms and frontier applications in IL-17A-induced hypertension

Figures

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  Figure 1. Interaction between IL-17A and other cytokines in renal fibrosis. Naive T-cells develop into Th17 cells under the stimulation of TGF-β and IL-6 and secrete IL-17A. On the other hand, anti-IL-17A or anti-IL-17 receptor A subunit monoclonal antibodies significantly reduced TGF-β levels in renal fibrosis.

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  Figure 2. Mechanisms of IL-17A-induced hypertension through multiple pathways in the vascular system (a), brain (b), intestinal microbiota (c), and kidneys (d). When the inflammation from gut microbiota gets further into the circulating bloodstream, the brain, autonomic nervous system, and kidneys will be affected.