Key result
In 6,994 observations, depression and anxiety were not significantly associated with cardiac autonomic dysregulation after adjusting for antidepressant use.
Why the study?
It is unclear whether the relationship between depression, anxiety, and cardiac autonomic dysregulation is causal or attributable to confounding factors.
Does antidepressant use confound the association between depression/anxiety and cardiac autonomic dysregulation?
Population
6,994 observations (65% female) in the Netherlands Study of Depression and Anxiety
Comparison
Depression, anxiety, and antidepressant use vs non-use
Design
Longitudinal cohort study
Follow-up
9 years
Authors
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Antidepressant use likely confounds observed links to autonomic dysregulation; leaves open independent effects of depression/anxiety in cohort data.
Cohort (n=6,994)
Does antidepressant use confound the association between depression/anxiety and cardiac autonomic dysregulation?
The apparent association between depression or anxiety and cardiac autonomic dysregulation is likely driven by the confounding effects of antidepressant medications rather than a direct causal link or genetic pleiotropy.
Hu et al. (2019) conducted a cohort in Depression and anxiety (n=6,994). Depression and anxiety was evaluated on Heart rate (HR) and heart rate variability (HRV). In 6,994 observations, depression and anxiety were not significantly associated with cardiac autonomic dysregulation after adjusting for antidepressant use.
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