Key result
Major depression was associated with significantly lower heart rate variability, including reduced SDNN (93.13 vs 110.57 ms2, p<0.01), and a higher prevalence of arrhythmias compared to healthy controls.
Why the study?
Does major depression alter cardiac autonomic function and increase the prevalence of arrhythmias compared to healthy controls?
Population
106 individuals, comprising 53 patients hospitalized for major depression and 53 healthy volunteers matched…
Comparison
Major depression vs Healthy volunteers matched for age and gender
Design
Case-control, Assessment of arrhythmias was conducted by a technician who was…
Follow-up
24 hours
Authors
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May signal arrhythmia risk in depression; hypothesis-generating and requires prospective validation before practice change.
Case-Control (n=106)
Single-blind
No
Does major depression alter cardiac autonomic function and increase the prevalence of arrhythmias compared to healthy controls?
Absolute Event Rate: 93.13% vs 110.57%
p-value: p=<0.01
Major depression is associated with significant cardiac autonomic dysfunction, characterized by reduced parasympathetic tone and increased sympathetic tone, as well as a higher prevalence of premature atrial and ventricular arrhythmias.
Wang et al. (2013) conducted a case-control in Major depression (n=106). Major depression vs. Healthy controls was evaluated on Standard deviation of the NN intervals (SDNN) (p=<0.01). Major depression was associated with significantly lower heart rate variability, including reduced SDNN (93.13 vs 110.57 ms2, p<0.01), and a higher prevalence of arrhythmias compared to healthy controls.
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