Key result
Higher BMI linked to a ~0.013 m/s increase in cfPWV per BMI unit in youth.
Why the study?
Exposure to modifiable factors is associated with early vascular ageing, but this has not been thoroughly assessed in youth.
Are modifiable factors such as BMI associated with early vascular ageing (measured by cfPWV) in youth?
Systematic Review
Are modifiable factors such as BMI associated with early vascular ageing (measured by cfPWV) in youth?
Effect estimate: 0.013 m/s per kg/m2
p-value: p=<0.0001
Higher BMI is significantly associated with increased arterial stiffness (cfPWV) in youth, highlighting the importance of early lifestyle interventions for vascular health.
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Supports BMI focus for youth vascular health; extends observational data but leaves open causal effects of intervention.
Kodithuwakku et al. (2025) conducted a systematic review in early vascular ageing. Body mass index was evaluated on carotid-to-femoral pulse wave velocity (cfPWV) (0.013 m/s per kg/m2, p=<0.0001). Body mass index was significantly associated with increased carotid-to-femoral pulse wave velocity in youth (0.013 m/s per kg/m2, P<0.0001).
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