From Gene Mutation to Sleep Phenotype: DEC2 in Natural Short Sleepers

This review focuses on the role of sleep in overall health, specifically its physiological activities, and the consequences of sleep disorders. We review the DEC2 gene mutation, which is associated with familial natural short sleep (FNSS) that allows people to remain healthy despite chronic sleep deprivation. This mutation not only extends life expectancy but also enhances stress resistance by influencing circadian rhythms and overall physiological responses. With the rising prevalence of sleep disruptions in modern culture, understanding genetic markers like the DEC2 provides critical insights into potential pro-longevity pathways, opening the way for approaches that maintain health during sleep deprivation and extend overall health span.