Key result
Brachial artery infusion of the nNOS-specific inhibitor SMTC caused a 30.1% decrease in basal flow at the highest dose (P<0.01), indicating nNOS regulates basal microvascular tone.
Why the study?
Does nNOS inhibition with SMTC reduce basal microvascular blood flow in healthy humans?
Population
Healthy subjects (n=10)
Comparison
Brachial artery infusion of the nNOS-specific… vs Nonselective NO synthase inhibitor…
Design
Other
Authors
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No immediate clinical implications in healthy subjects; leaves open nNOS as a therapeutic target in microvascular disease.
Does nNOS inhibition with SMTC reduce basal microvascular blood flow in healthy humans?
Absolute Event Rate: 30.1% vs 37.4%
p-value: p=<0.01
Neuronal nitric oxide synthase (nNOS) plays a distinct local role in regulating basal human microvascular tone in vivo, separate from eNOS.
Seddon et al. (2008) studied Healthy subjects (n=10). S-methyl-L-thiocitrulline (SMTC) vs. N(G)-monomethyl-L-arginine (L-NMMA) was evaluated on Reduction in basal flow (p=<0.01). Brachial artery infusion of the nNOS-specific inhibitor SMTC caused a 30.1% decrease in basal flow at the highest dose (P<0.01), indicating nNOS regulates basal microvascular tone.
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