The ability of strains of Bacteroides fragilis resistant to clindamycin and/or tetracycline to transfer resistance to a susceptible recipient strain in experimental subcutaneous abscesses in mice was investigated. The results indicated that such transfer took place at a frequency similar to that observed in vitro. Transfer of resistance determinants at infected sites may play a role in the epidemiology of disseminated resistance to antimicrobial agents.
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Butler et al. (1984) studied this question.
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