Key result
Atomic force microscopy revealed that the single molecule persistence lengths of cardiac titin's PEVK domain and N2B-Us spring elements are ~1.4 nm and ~0.65 nm, respectively.
The mechanical characteristics of titin's PEVK and N2B-Us spring elements explain the physiological levels of passive force in moderately to highly stretched myocardium.
Titin spring mechanics may explain myocardial passive force in animals; leaves open human translation and clinical relevance.
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Watanabe et al. (2002) studied this question. Atomic force microscopy of PEVK and N2B-Us spring elements was evaluated on Persistence length of PEVK domain and N2B-Us. Atomic force microscopy revealed that the single molecule persistence lengths of cardiac titin's PEVK domain and N2B-Us spring elements are ~1.4 nm and ~0.65 nm, respectively.
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