Key result
In frog sartorius muscle, the rate of oxygen consumption declines monoexponentially after a tetanus and changes in parallel with creatine and phosphorylcreatine levels.
Population
Frog sartorius muscle (Rana pipiens and Rana temporaria)
Design
Preclinical
Authors
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Supports creatine shuttle in amphibian muscle; leaves open relevance to mammalian cardiac bioenergetics.
The first-order kinetics of muscle oxygen consumption are consistent with the hypothesis that respiration is rate-limited by the mitochondrial creatine kinase reaction, supporting the 'creatine shuttle' hypothesis.
Michael E. Mahler (1985) studied this question. Tetanus at 20 degrees C was evaluated on Rate of O2 consumption (QO2) and phosphorylcreatine levels. In frog sartorius muscle, the rate of oxygen consumption declines monoexponentially after a tetanus and changes in parallel with creatine and phosphorylcreatine levels.
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