April 1, 1998Journal of Biological ChemistryOpen Access

Mechanisms Involved in the Acidosis Enhancement of the Isoproterenol-induced Phosphorylation of Phospholamban in the Intact Heart

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Population

Isolated Langendorff perfused hearts from male Wistar rats (250-350 g body weight)

Comparison

Acidosis in the presence of isoproterenol vs Normal pH in the presence of isoproterenol

Design

Preclinical

Authors

LVLeticia VittoneConsejo Nacional de Investigaciones Científicas y Técnicas CMCecilia Mundiña‐WeilenmannCentro Científico Tecnológico - La Plata MSMatilde SaidCentro de Investigaciones Cardiovasculares

Discussion

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Implication

Acidotic pH may modulate cardiac beta-adrenergic signaling in animals; leaves open relevance to human ischemia or HF.

Structured PICO

Population

Isolated Langendorff perfused hearts from male Wistar rats (250-350 g body weight)

Intervention

Acidosis (pHo 6.80) in the presence of isoproterenol (3-300 nm)

Comparator

Normal pH (pHo 7.40) in the presence of isoproterenol

Outcome

Phosphorylation of Thr17 and Ser16 of phospholamban and relaxant effectsurrogate

Acidosis enhances isoproterenol-induced phospholamban phosphorylation in the intact heart via an increase in intracellular calcium and inhibition of phosphatases, specifically targeting the Thr17 residue.

Cite This Study

Vittone et al. (1998) studied this question.

synapsesocial.com/papers/6a2054611d7d35d060d1f3ce https://doi.org/10.1074/jbc.273.16.9804

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Mechanisms Involved in the Acidosis Enhancement of the Isoproterenol-induced Phosphorylation of Phospholamban in the Intact Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms Involved in the Acidosis Enhancement of the Isoproterenol-induced Phosphorylation of Phospholamban in the Intact Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider