Key result
Chronic stress acts as a key element uniting cellular impacts on coronary microcirculation, leading to endothelial dysfunction and cardiovascular disease through allostatic load.
Understanding the psychoneuroendocrine mechanisms of stress and allostatic load provides a framework for addressing endothelial dysfunction and cardiovascular disease risk.
May inform stress-targeted approaches to endothelial dysfunction; hypothesis-generating pending prospective trials.
Stress is the key element that unites all the influences that have a cellular impact in the coronary microcirculation, determining serious consequences for health. In particular, mental stress does not differ from the physical stress and is always part of the biological processes that are examined in the research and daily clinical practice. Many cardiovascular diseases occur after a long process of stress, compensation and exhaustion, after accumulating some allostatic load. The stress reaction is common both at a macroscopic level both at the cellular level. We move forward considering the biological cellular balance, especially cardiovascular one, in molecular and atomic terms, with reference to the newest achievements in the field of quantum physics. The above leads inevitably to raise three important issues that must be solved in order to progress effectively in scientific research.
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Lin et al. (2015) conducted a review in Cardiovascular disease and stress. Stress and psychoneuroendocrine immunitary signals was evaluated. Chronic stress acts as a key element uniting cellular impacts on coronary microcirculation, leading to endothelial dysfunction and cardiovascular disease through allostatic load.
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