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Striatal dopamine D2 receptor binding was studied in vivo with positron emission tomography in seven patients with early Parkinson's disease using 11C-raclopride. The patients had unilateral symptoms and none of them had received levodopa treatment. The accumulation of 11C-raclopride in the striatum was rapid and reached a steady state at approximately 40 min after injection. The binding of 11C-raclopride was measured in the striatum and cerebellum: The total striatal radioactivity in both hemispheres was counted and the respective striatum/cerebellum ratios were calculated. The striatum/cerebellum ratio of 11C-raclopride binding was significantly (p less than 0.01) increased in the hemisphere contralateral to the parkinsonian symptoms as compared with the opposite hemisphere. Thus, this study demonstrates that there is denervation supersensitivity in dopamine D2 receptor binding in early Parkinson's disease.
Rinne et al. (Mon,) studied this question.