February 26, 2001Archives of Internal Medicine
Aspirin and the Treatment of Heart Failure in the Elderly
Key result
Aspirin prescription at discharge was associated with lower 1-year mortality in older patients with heart failure and coronary artery disease (OR 0.71; 95% CI 0.54-0.94).
Why the study?
Does aspirin prescription at discharge reduce 1-year mortality in elderly patients hospitalized with heart failure and coronary artery disease?
Population
1,110 Medicare beneficiary survivors aged ≥65 years hospitalized with both heart failure and coronary artery…
Comparison
Aspirin prescribed as a discharge medication vs Not prescribed aspirin at discharge
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Should not yet change practice in older HF-CAD patients; leaves open whether discharge aspirin reduces mortality.
Key Points
- The study aims to assess aspirin prescription rates and its association with 1-year survival in elderly heart failure patients.
- Retrospective cohort study of Medicare beneficiaries hospitalized for heart failure in 18 Connecticut hospitals.
- Sample included 1110 patients without contraindications to aspirin therapy.
- Aspirin prescription rates and mortality were evaluated at discharge and 1 year post-discharge.
- 41% of patients were prescribed aspirin at discharge.
- Those prescribed aspirin had a 1-year mortality odds ratio of 0.71 (95% CI, 0.54-0.94).
- Lower mortality was observed for aspirin patients even after adjusting for baseline characteristics.
Study Design
Type
Cohort (n=1,110)
Multicenter
Yes
Structured PICO
Does aspirin prescription at discharge reduce 1-year mortality in elderly patients hospitalized with heart failure and coronary artery disease?
P
Population
1,110 Medicare beneficiaries aged 65 years or older hospitalized with heart failure and coronary artery disease, followed for 1 year.
E
Exposure
Aspirin prescribed as a discharge medication
C
Comparator
Not prescribed aspirin at discharge
O
Outcome
1-year mortality after dischargehard clinical
Main Result
Odds Ratio: 0.71 (95% CI 0.54–0.94)
Aspirin prescription at discharge is associated with lower 1-year mortality in older patients with both heart failure and coronary artery disease.
Cite This Study
Krumholz et al. (2001) conducted a cohort in Heart failure and coronary artery disease (n=1,110). Aspirin prescription at discharge vs. No aspirin prescribed at discharge was evaluated on 1-year mortality (OR 0.71, 95% CI 0.54-0.94). Aspirin prescription at discharge was associated with lower 1-year mortality in older patients with heart failure and coronary artery disease (OR 0.71; 95% CI 0.54-0.94).