Why the study?
How do brain and cerebrospinal fluid concentrations of lipophilic versus hydrophilic beta-blockers compare in neurosurgical patients?
How do brain and cerebrospinal fluid concentrations of lipophilic versus hydrophilic beta-blockers compare in neurosurgical patients?
Lipophilic beta-blockers penetrate the brain at substantially higher concentrations than hydrophilic beta-blockers, which may explain their higher propensity for central nervous system side effects.
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May warrant preferring hydrophilic agents to limit CNS effects; leaves open confirmation in larger cardiovascular cohorts.
Cruickshank et al. (1980) studied this question.
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