Post-myocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study.

77 patients with acute myocardial infarction within the previous 6-30 days and 10 or more ventricular premature depolarizations (VPDs)/hr or one or more runs of ventricular tachycardia on 24-hour electrocardiographic recording

Amiodarone (loading dose 10 mg/kg/day for 3 weeks, maintenance dose 300-400 mg/day with reductions at 4-month intervals)

Placebo

VPD suppression, arrhythmic death or resuscitated ventricular fibrillation, and all-cause mortalityhard clinical