September 1, 1990Circulation
Spontaneous variability in ventricular ectopic activity during chronic antiarrhythmic therapy.
Why the study?
What is the spontaneous variability in ventricular ectopic activity during chronic effective antiarrhythmic therapy in patients with chronic arrhythmias?
Population
55 patients with chronic arrhythmias who underwent multiple ambulatory electrocardiographic recordings…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Single Holter increases may not signal antiarrhythmic failure; leaves open optimal serial monitoring protocols for chronic PVC cohorts.
Structured PICO
What is the spontaneous variability in ventricular ectopic activity during chronic effective antiarrhythmic therapy in patients with chronic arrhythmias?
P
Population
55 patients with chronic arrhythmias who underwent multiple ambulatory electrocardiographic recordings during evaluation of chronic therapy with antiarrhythmic drugs initially determined to be effective (defined as 70% or more reduction in total PVC frequency or 90% or more reduction in repetitive forms).
I
Intervention
Chronic therapy with antiarrhythmic drugs
O
Outcome
Variability in the percent suppression of premature ventricular complexes (PVCs)surrogate
Substantial spontaneous variability in arrhythmia frequency occurs during effective antiarrhythmic therapy, suggesting that a single Holter test showing increased arrhythmia frequency may not necessarily indicate treatment failure.
Cite This Study
Anderson et al. (1990) studied this question.