Key result
A single 100 to 150 mg oral dose of aprindine hydrochloride effectively reduced ventricular premature contractions by at least 80% for 2 or more consecutive hours in 58% of patients.
Why the study?
What are the pharmacokinetic properties and clinical effects on ventricular premature contractions of a single oral dose of aprindine hydrochloride?
Population
29 patients with frequent ventricular premature contractions (VPCs)
Design
Cohort
Follow-up
up to 11 hours post-administration for Holter monitoring
Authors
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May inform acute VPC dosing via plasma levels; hypothesis-generating and requires RCTs before practice change.
What are the pharmacokinetic properties and clinical effects on ventricular premature contractions of a single oral dose of aprindine hydrochloride?
A single oral dose of aprindine hydrochloride effectively reduces frequent ventricular premature contractions with a mean effective time of 7.8 hours and a minimal effective plasma level of 0.38 μg/ml.
Yokota et al. (1985) studied Frequent ventricular premature contractions (VPCs) (n=29). Aprindine hydrochloride vs. Baseline (pre-administration) was evaluated on Proportion of patients with at least an 80% decrease in VPCs per hour for 2 or more consecutive hours. A single 100 to 150 mg oral dose of aprindine hydrochloride effectively reduced ventricular premature contractions by at least 80% for 2 or more consecutive hours in 58% of patients.
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