Why the study?
Emerging data suggest lipid disorders may be linked to AF, but a comprehensive synthesis of current evidence and potential underlying mechanisms was needed.
Does lipid profile variation affect the incidence and prevalence of atrial fibrillation?
Does lipid profile variation affect the incidence and prevalence of atrial fibrillation?
This review highlights a 'cholesterol paradox' where lower levels of LDL-C, TC, and HDL-C are associated with an increased risk of atrial fibrillation, suggesting complex lipid-related mechanisms in AF pathogenesis.
Challenges conventional lipid-AF assumptions; leaves open mechanisms and requires prospective validation before clinical consideration.
Atrial fibrillation (AF) is the most common type of symptomatic arrhythmias, which was induced by multiple causes and dyslipidemia is a well-known causal factor for the atherosclerotic cardiovascular disease (ASCVD). Interestingly, emerging data has suggested that lipid disorder may be also associated with AF. Several previous studies have shown a link of the prevalence of AF with decreased concentration of low-density lipoproteins (LDL)-cholesterol, total cholesterol (TC), high-density lipoproteins (HDL)-cholesterol, and elevated lipoprotein(a) [Lp(a)]. In this manuscript, we try to summarize the current evidence regarding the relation of dyslipidemia to the incident AF, present the potential lipid-related mechanisms of AF development, which is involved in cell membrane properties, LDL-receptors reduction, reverse cholesterol transport, adiposity-induced inflammation, apoptosis, and autophagy. Such information may boost our understandings concerning the lipid disorder and AF, which may help future exploration in the link of dyslipidemia and AF.
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Jiang et al. (2022) conducted a review in Atrial fibrillation and dyslipidemia. Lipid profile (LDL-C, TC, HDL-C, TG, Lp(a)) was evaluated on Incident atrial fibrillation.
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