Key result
Higher LDL cholesterol (top vs bottom quintile) was inversely associated with incident atrial fibrillation (HR 0.72; 95% CI 0.56-0.92; P=0.009).
Why the study?
Do higher lipoprotein measures reduce incident atrial fibrillation in healthy middle-aged and older women?
Cohort (n=23,738)
Do higher lipoprotein measures reduce incident atrial fibrillation in healthy middle-aged and older women?
Hazard Ratio: 0.72 (95% CI 0.56–0.92)
p-value: p=0.009
Higher levels of LDL cholesterol and other atherogenic lipoproteins are paradoxically associated with a lower risk of incident atrial fibrillation in healthy women.
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Observed inverse LDL-AF link should not alter lipid management; hypothesis-generating for lipoprotein effects on arrhythmia risk.
Mora et al. (2014) conducted a cohort in Incident atrial fibrillation (n=23,738). LDL cholesterol (top quintile) vs. Bottom quintile was evaluated on Incident atrial fibrillation (HR 0.72, 95% CI 0.56-0.92, p=0.009). Higher LDL cholesterol (top vs bottom quintile) was inversely associated with incident atrial fibrillation (HR 0.72; 95% CI 0.56-0.92; P=0.009).
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