Key result
High total cholesterol in midlife was associated with a lower risk of atrial fibrillation within 5 years (HR 0.61), while low HDL-C and ApoA-I were associated with increased risk over 35 years.
Why the study?
The role of cholesterol levels in the development of AF remains controversial, and the association between apolipoproteins and AF risk is rarely studied.
Are midlife blood lipid levels associated with the subsequent risk of new-onset atrial fibrillation in individuals without overt cardiovascular disease?
Cohort (n=65,136)
Are midlife blood lipid levels associated with the subsequent risk of new-onset atrial fibrillation in individuals without overt cardiovascular disease?
Hazard Ratio: 0.61 (95% CI 0.41–0.99)
p-value: p=0.013
Metabolic syndrome and inflammation markers (low HDL-C, high TG/HDL-C ratio), rather than high LDL-C, are associated with long-term incident atrial fibrillation risk.
Midlife lipids may refine AF risk models; leaves open causal effects and need for trials.
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Ding et al. (2022) conducted a cohort in Atrial fibrillation (n=65,136). High total cholesterol and LDL-C vs. Reference lipid levels was evaluated on Incident atrial fibrillation (first 5 years of follow-up) (HR 0.61, 95% CI 0.41 to 0.99, p=0.013). High total cholesterol in midlife was associated with a lower risk of atrial fibrillation within 5 years (HR 0.61), while low HDL-C and ApoA-I were associated with increased risk over 35 years.
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