Key result
Middle total cholesterol trajectories linked to ~2.7 years longer CV event-free survival versus low trajectories.
Why the study?
The relationship between lipid profiles over time and cardiovascular outcomes in elderly Asian patients with atrial fibrillation remains unexplored.
Are trajectories of lipid profile changes associated with composite cardiovascular outcomes in elderly Asian patients with atrial fibrillation?
Cohort (n=823)
Are trajectories of lipid profile changes associated with composite cardiovascular outcomes in elderly Asian patients with atrial fibrillation?
In elderly Asian patients with atrial fibrillation, middle trajectories of total cholesterol and LDL, as well as persistently higher HDL trajectories, are associated with longer cardiovascular event-free survival compared to low trajectories.
Answers are grounded in this paper and cite their sources.
Middle cholesterol trajectories were associated with longer event-free survival in elderly Asian AF; hypothesis-generating for trajectory-based risk stratification.
Background The relationship between baseline total cholesterol, low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and cardiovascular outcomes is well established, but their trajectories over time in elderly Asian patients with atrial fibrillation (AF) remain unexplored. Methods and Results Using the Taipei Medical University Clinical Research Database from 2013 to 2020, we identified 823 AF patients aged above 75 with at least three annual lipid profile measurements. We used an accelerated failure time (AFT) model to examine the association of trajectories with the primary outcome of composite cardiovascular events (stroke, TIA, myocardial infarction, heart failure hospitalization and cardiovascular death). During follow‐up, 308 patients developed events (61.33 per 100 person‐years). Three total cholesterol trajectory groups were identified: low (group 1), decreasing (group 2), and middle (group 3). Compared with group 1, individuals in group 3 exhibited a significantly longer event‐free survival, with a mean increase of 2.74 years (95% confidence interval [CI]: 1.05–7.12; p = 0.0394). For LDL trajectories, group 3 was associated with a mean increase of 2.35 years (95% CI: 1.11–4.98; p = 0.0252) in survival time from the primary outcome compared to group 1. Regarding HDL, participants in group 3—characterized by persistently higher HDL levels—had a 2.12‐year longer survival time (95% CI: 1.01–4.43; p = 0.0456) compared to those in group 1. Triglyceride trajectories showed no significant association with the primary outcome. Conclusion In this hospital‐based cohort study, total cholesterol, LDL, and HDL trajectories are associated with composite cardiovascular outcomes in elderly Asian AF patients.
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Wang et al. (2025) conducted a cohort in Atrial Fibrillation (n=823). Lipid profile trajectories (total cholesterol, LDL, HDL) vs. Low trajectory group (group 1) was evaluated on Composite cardiovascular events (stroke, TIA, myocardial infarction, heart failure hospitalization and cardiovascular death) (Mean increase 2.74 years, 95% CI 1.05-7.12, p=0.0394). Middle total cholesterol trajectories were associated with longer cardiovascular event-free survival compared to low trajectories (mean increase 2.74 years; 95% CI 1.05-7.12; p=0.0394).
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