Key result
Impaired cerebral vasomotor reactivity is weakly linked to greater carotid intima-media thickness.
Why the study?
To investigate the correlation between carotid artery stenosis measured by ultrasonographic morphological and hemodynamic parameters and cerebral vasomotor reactivity.
Cross-Sectional (n=285)
No
Ultrasonographic morphological changes of the carotid arteries, such as increased intima-media thickness and the presence of plaques, significantly negatively correlate with cerebral vasomotor reactivity, indicating they may serve as early markers of small cerebral vessel functional decline.
Answers are grounded in this paper and cite their sources.
Carotid IMT was associated with impaired vasomotor reactivity; hypothesis-generating for large- versus small-vessel links, needs prospective validation.
The function of cerebral small vessels can be assessed using cerebral vasomotor reactivity (VMR). Our aim in this retrospective cross-sectional study was to investigate a correlation between carotid artery stenosis measured through ultrasonographic morphological and hemodynamic parameters and cerebral VMR. A total of 285 patients (125 males; mean age 54) were included. The breath-holding index (BHI) was used to evaluate cerebral VMR. Ultrasonographic carotid artery parameters were collected: the presence and characteristics of carotid plaques, the degree of carotid diameter stenosis, intima–media thickness (IMT), peak systolic velocity (PSV), and end diastolic velocity (EDV). Additionally, hemodynamic parameters of the middle cerebral artery (MCA) were evaluated, including the mean flow velocity (MFV) and pulsatility index (PI). The following was collected from patients’ medical histories: age, gender, and vascular risk factors. A negative correlation between the BHI and age (r = −0.242, p < 0.01), BHI and the presence of carotid plaques, BHI and IMT (r = −0.203, p < 0.01), and BHI and the PI of MCA on both sides (r = −0.268, p < 0.01) was found. We found a positive correlation between the BHI in the left MCA and EDV in the left internal carotid artery (r = 0.121, p < 0.05). This study shows the correlation between cerebral VMR and carotid stenosis but indicates a higher influence of morphological parameters on VMR values.
No takes yet. Share an insight, caveat, or question.
Stoisavljevic et al. (2024) conducted a cross-sectional in Patients evaluated for cerebral vasomotor reactivity and carotid artery stenosis (n=285). Ultrasonographic morphological and hemodynamic evaluation of carotid arteries was evaluated on Correlation between breath-holding index (BHI) and carotid intima-media thickness (IMT) (r = -0.203, p=<0.01). Cerebral vasomotor reactivity (measured by BHI) had a significant negative correlation with carotid intima-media thickness (r = -0.203, p < 0.01) and middle cerebral artery pulsatility index.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: