Key result
Severe carotid stenosis and symptomatic disease are linked to impaired cerebral vasomotor reactivity.
Why the study?
The relationship between carotid artery disease severity and cerebral vasomotor reactivity, as well as the influence of vascular risk factors on these parameters, was not well characterized.
Does severe carotid stenosis impair vasomotor reactivity of cerebral blood vessels?
Case-Control (n=80)
Does severe carotid stenosis impair vasomotor reactivity of cerebral blood vessels?
p-value: p=0.004
Severe carotid stenosis (>70%) and symptomatic carotid disease significantly impair cerebral vasomotor reactivity, which may increase the risk of stroke.
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VMR assessment may refine risk stratification in carotid stenosis; leaves open whether risk factors independently impair reactivity.
Krdžić et al. (2014) conducted a case-control in Carotid stenosis (n=80). Carotid stenosis vs. Controls was evaluated on Vasomotor reactivity reduction (breath holding index < 0.69) (p=0.004). Severe carotid stenosis (>70%) and symptomatic carotid disease significantly impaired cerebral vasomotor reactivity (P=0.004 and P<0.05, respectively).
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