Key result
Transfer function analysis of cerebral hemodynamics revealed that low-frequency phase angle was negatively correlated with the severity of carotid stenosis (r=-0.53, P<0.001).
Why the study?
Does transfer function analysis of spontaneous fluctuations of ABP and MCAFV accurately assess cerebral autoregulation in patients with carotid stenosis?
Population
120 participants (83 consecutive patients with various degrees of carotid stenosis and 37 healthy controls)
Comparison
Transfer function analysis of spontaneous… vs Healthy controls and contralateral unaffected…
Design
Cross-sectional
Authors
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May support transfer function analysis for noninvasive autoregulation assessment in carotid stenosis; leaves open prospective validation before clinical use.
Observational (n=120)
Does transfer function analysis of spontaneous fluctuations of ABP and MCAFV accurately assess cerebral autoregulation in patients with carotid stenosis?
Effect estimate: r=-0.53
p-value: p=<0.001
Transfer function analysis of spontaneous fluctuations of MCAFV and ABP is a valid, noninvasive method to identify hemodynamically significant high-grade carotid stenosis with impaired cerebral autoregulation.
Hu et al. (1999) conducted an observational in Carotid Stenosis (n=120). Transfer function analysis of cerebral hemodynamics vs. Healthy controls was evaluated on Correlation of low-frequency (LF) phase angle with severity of stenosis (r=-0.53, p=<0.001). Transfer function analysis of cerebral hemodynamics revealed that low-frequency phase angle was negatively correlated with the severity of carotid stenosis (r=-0.53, P<0.001).
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