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January 1, 1974CancerOpen Access

Conservative management of malignant pericardial effusion

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Why the study?

Does conservative management with local instillation of chemotherapeutic agents ± radiotherapy improve symptoms in patients with malignant pericardial effusion?

Population

5 patients with antemortem diagnoses of malignant pericardial disease with predominant pericardial effusion…

Comparison

Conservative management with local instillation… vs Surgical programs utilizing pericardial window

Design

Case_series

Follow-up

Up to 40 months

Authors

FSFrank E. SmithChampions Oncology (United States)MLMontague LaneNational Institutes of HealthPHPhilip T. HudginsHouston Methodist

Discussion

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Implication

Local chemotherapy ± radiotherapy may relieve malignant pericardial effusion symptoms; hypothesis-generating, needs prospective trials versus surgery.

Structured PICO

Does conservative management with local instillation of chemotherapeutic agents ± radiotherapy improve symptoms in patients with malignant pericardial effusion?

P
Population
5 patients with antemortem diagnoses of malignant pericardial disease with predominant pericardial effusion causing tamponade
I
Intervention
Conservative management with local instillation of a chemotherapeutic agent ± radiotherapy
C
Comparator
Surgical programs utilizing pericardial window (based on literature review)
O
Outcome
Complete response with total disappearance of cardiac symptoms and signspatient reported

Conservative management with local chemotherapy and/or radiotherapy may be an effective alternative to surgical pericardial window for malignant pericardial effusion.

Cite This Study

Smith et al. (1974) studied this question.

synapsesocial.com/papers/6a206640e41fe89b4c9cd76ehttps://doi.org/10.1002/1097-0142(197401)33:1<47::aid-cncr2820330110>3.0.co;2-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Secondary Malignant Tumors of the Pericardium1962 · 214 citations
  2. 2TUMORS OF THE HEART. II. REPORT OF A SECONDARY TUMOR OF THE HEART INVOLVING THE PERICARDIUM AND THE BUNDLE OF HIS WITH REMISSION FOLLOWING DEEP ROENTGEN-RAY THERAPY1940 · 33 citations
  3. 3PERICARDIAL TAMPONADE1954 · 56 citations
  4. 4Tumor Metastasis to the Heart1954 · 115 citations
  5. 5Pericardial and myocardial involvement by lymphomas and leukemias.The role of radiotherapy1970 · 78 citations