Key result
Super-resolution reconstruction of LGE MRI significantly reduced myocardial scar gray zone sizes compared to standard short-axis volumes (9.2 ± 8.1 g vs. 10.5 ± 8.8 g, P < 0.05).
Why the study?
Does super-resolution reconstruction of LGE MRI improve myocardial scar assessment compared to standard short-axis volume in postinfarction patients?
Observational (n=37)
Does super-resolution reconstruction of LGE MRI improve myocardial scar assessment compared to standard short-axis volume in postinfarction patients?
Absolute Event Rate: 9.2% vs 10.5%
p-value: p=< 0.05
Super-resolution reconstruction of LGE MRI from three orthogonal views improves myocardial scar assessment compared to standard short-axis imaging alone.
Super-resolution LGE MRI may refine gray zone quantification; hypothesis-generating and should not yet change post-MI scar assessment.
PURPOSE: To develop and validate a method for improving image resolution of late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) for accurate assessment of myocardial scar. MATERIALS AND METHODS: In a cohort of 37 postinfarction patients, LGE was performed prior to ventricular tachycardia catheter ablation therapy at 1.5T. A super-resolution reconstruction (SRR) technique was applied to the three anisotropic views: short-axis (SA), two-chamber, and four-chamber, to reconstruct a single isotropic volume. For compensation of the interscan heart motion, a joint localized gradient-correlation-based scheme was developed. Scar was identified as either core or gray zone in both the SRR and original SA volumes, and evaluated based on the clinically established bipolar voltage range of the in vivo electroanatomical voltage mapping (EAVM). RESULTS: Compared to the SA volume, the SRR method resulted in significantly (P < 0.05) reduced myocardial scar gray zone sizes (10.5 ± 8.8 g vs. 9.2 ± 8.1 g) and improved agreement of the bipolar voltage range of scar gray zone (0.99 ± 0.65 mV vs. 1.46 ± 1.15 mV). CONCLUSION: We propose an SRR method to automatically reconstruct a high-quality isotropic LGE volume from three orthogonal views. Analysis of the in vivo EAVM demonstrated improved myocardial scar assessment from the SRR volume compared with the SA LGE alone.
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Dzyubachyk et al. (2014) conducted an observational in Postinfarction (n=37). Super-resolution reconstruction (SRR) technique vs. Original short-axis (SA) volumes was evaluated on Myocardial scar gray zone size (g) (p=< 0.05). Super-resolution reconstruction of LGE MRI significantly reduced myocardial scar gray zone sizes compared to standard short-axis volumes (9.2 ± 8.1 g vs. 10.5 ± 8.8 g, P < 0.05).
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