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September 14, 2022BMC Cardiovascular DisordersOpen Access

Prediction of microvascular obstruction by coronary artery angiography score after acute ST-segment elevation myocardial infarction: a single-center retrospective observational study

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Key result

The SYNTAX II score was identified as an independent predictor of microvascular obstruction in patients with acute STEMI undergoing primary PCI (OR 11.636).

Why the study?

Quality evidence regarding the association between coronary artery angiography scores and microvascular injury in acute STEMI after PCI is still needed.

Do coronary artery angiography scores predict microvascular obstruction detected by CMR in patients with acute STEMI undergoing primary PCI?

Population

122 patients with acute STEMI who underwent primary PCI and CMR

Comparison

MVO group vs non-MVO group based on CMR results

Design

Single-center retrospective observational study

Authors

ZLZiwen LiHYHongbin YinDWDehua Wang

Discussion

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Overview

May aid MVO risk stratification post-STEMI; leaves open prospective validation before clinical adoption.

Study Design

Type

Observational (n=122)

Multicenter

No

Structured PICO

Do coronary artery angiography scores predict microvascular obstruction detected by CMR in patients with acute STEMI undergoing primary PCI?

P
Population
122 patients (mean age 60.6 years, 27.9% female) with acute STEMI who underwent primary PCI, evaluated for microvascular obstruction via CMR 3 to 7 days post-procedure.
E
Exposure
Coronary artery angiography (CAG) scores (SYNTAX score, SYNTAX II score and Gensini score)
O
Outcome
Microvascular obstruction (MVO) detected by cardiac magnetic resonance (CMR) imaging performed between 3 and 7 days after PCIsurrogate

Main Result

Odds Ratio: 11.636 (95% CI 1.816–74.556)

p-value: p=0.010

The SYNTAX II score and peak troponin I are independent predictors of microvascular obstruction in patients with acute STEMI undergoing primary PCI.

Limitations

  • Single-center study with a small sample size
  • Observational retrospective design may have resulted in bias in information selection
  • Angiography-based visual scoring may be affected by observer subjective factors

Cite This Study

Li et al. (2022) conducted an observational in Acute ST-segment elevation myocardial infarction (STEMI) (n=122). SYNTAX II score vs. Lower scores was evaluated on Microvascular obstruction (MVO) detected by cardiac magnetic resonance (OR 11.636, 95% CI 1.816-74.556, p=0.010). The SYNTAX II score was identified as an independent predictor of microvascular obstruction in patients with acute STEMI undergoing primary PCI (OR 11.636).

synapsesocial.com/papers/6a2071809c0ff40d0e780234https://doi.org/10.1186/s12872-022-02836-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Value of Fast MVO Identification From Contrast-Enhanced Cine (CE-SSFP) Combined With Myocardial Strain in Predicting Adverse Events in Patients After ST-Elevation Myocardial Infarction2022 · 9 citations
  2. 2Prognostic value of the SYNTAX score on myocardial injury and salvage in STEMI patients after primary percutaneous coronary intervention: a single-center retrospective observational study2021 · 8 citations
  3. 3Application of the SYNTAX score in interventional cardiology2017 · 58 citations
  4. 4Identification of patients at higher risk for myocardial injury following elective coronary artery intervention2019 · 7 citations
  5. 52017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation2017 · 9,920 citations