Key result
Phonocardiography QS1 interval matches NT-proBNP in predicting elevated E/e', achieving an AUC of ~0.72.
Why the study?
HFpEF is associated with stiffened myocardium and elevated filling pressure that may be captured by heart sounds, but the relationship between phonocardiography and echocardiography in suspected HFpEF required investigation.
Does phonocardiography predict elevated E/e' ratio > 9 as accurately as NT-proBNP in symptomatic patients suspected of HFpEF?
Observational (n=45)
Double-blind (test interpreters blinded)
No
Does phonocardiography predict elevated E/e' ratio > 9 as accurately as NT-proBNP in symptomatic patients suspected of HFpEF?
Effect estimate: AUC 0.72 (95% CI 0.51-0.88)
Absolute Event Rate: 0.72% vs 0.67%
p-value: p=>0.05
Phonocardiography, particularly utilizing the QS1 interval, provides a simple, non-invasive method for evaluating elevated left ventricular filling pressure in suspected HFpEF patients, demonstrating diagnostic performance comparable to NT-proBNP.
QS1 may support noninvasive estimation of elevated filling pressures in suspected HFpEF; leaves open whether phonocardiography can supplant NT-proBNP in practice.
Aims Heart failure with preserved ejection fraction (HFpEF) is associated with stiffened myocardium and elevated filling pressure that may be captured by heart sound (HS). We investigated the relationship between phonocardiography (PCG) and echocardiography in symptomatic patients suspected of HFpEF. Methods and results Consecutive symptomatic patients with sinus rhythm and left ventricular ejection fraction >45% were enrolled. Echocardiography was performed to evaluate the patients’ diastolic function, accompanied by PCG measurements. Phonocardiography features including HS amplitude, frequency, and timing intervals were calculated, and their abilities to differentiate the ratio between early mitral inflow velocity and early diastolic mitral annular velocity (E/e′) were investigated. Of 45 patients, variable ratio matching was applied to obtain two groups of patients with similar characteristics but different E/e′. Patients with a higher E/e′ showed higher first and second HS frequencies and more fourth HS and longer systolic time intervals. The interval from QRS onset to first HS was the best feature for the prediction of E/e′ > 9 [area under the curve (AUC): 0.72 (0.51–0.88)] in the matched patients. In comparison, N-terminal pro-brain natriuretic peptide (NT-proBNP) showed an AUC of 0.67 (0.46–0.85), a value not better than any PCG feature (P > 0.05). Conclusion Phonocardiography features stratify E/e′ in symptomatic patients suspected of HFpEF with a diagnostic performance similar to NT-proBNP. Heart sound may serve as a simple non-invasive tool for evaluating HFpEF patients.
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Luo et al. (2022) conducted an observational in Symptomatic patients suspected of heart failure with preserved ejection fraction (HFpEF) (n=45). Phonocardiography (QS1 interval) vs. NT-proBNP was evaluated on Prediction of E/e' > 9 (AUC 0.72, 95% CI 0.51-0.88, p=>0.05). The phonocardiography interval from QRS onset to first heart sound (QS1) predicted an E/e' ratio > 9 with an AUC of 0.72, demonstrating diagnostic performance similar to NT-proBNP.
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