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July 17, 2009Cardiovascular ResearchOpen Access

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy

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Population

Patients with hypertrophic cardiomyopathy (HCM)

Design

Review

Authors

LCL. CarrierUniversität HamburgSSSaskia SchlossarekUniversität HamburgMWMonte S. WillisHeart Failure & Transplant

Discussion

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Implication

NMD/UPS pathways merit targeted HCM research; leaves open clinical translation pending interventional trials.

Structured PICO

P
Population
Patients with hypertrophic cardiomyopathy (HCM)

This review highlights the roles of nonsense-mediated mRNA decay and the ubiquitin-proteasome system in the pathogenesis of hypertrophic cardiomyopathy and their potential as therapeutic targets.

Cite This Study

Carrier et al. (2009) studied this question.

synapsesocial.com/papers/6a2071daa40bcbc79e09917fhttps://doi.org/10.1093/cvr/cvp247

Topics

Hypertrophic cardiomyopathyHeart failureHFrEF treatment
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