Why the study?
Are ACE2 gene polymorphisms associated with the risk and severity of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy?
Population
261 consecutive patients with hypertrophic cardiomyopathy (HCM) and 609 healthy controls
Comparison
Presence of ACE2 gene polymorphisms vs Absence of these polymorphisms / healthy controls
Design
Case-control
Authors
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Hypothesis-generating for ACE2 in HCM susceptibility and LVH severity; prospective validation needed before clinical use.
Are ACE2 gene polymorphisms associated with the risk and severity of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy?
Wang et al. (2008) studied this question.
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