Key result
ACE2 rs2106809 T allele linked to ~24% greater lone AF risk in Chinese males.
Why the study?
Are ACE2 gene polymorphisms associated with an increased risk of lone atrial fibrillation and adverse cardiac events in a Chinese Han population?
Case-Control (n=554)
Are ACE2 gene polymorphisms associated with an increased risk of lone atrial fibrillation and adverse cardiac events in a Chinese Han population?
Odds Ratio: 1.24 (95% CI 1.01–1.52)
p-value: p=0.03
The rs2106809 T allele of the ACE2 gene is associated with an increased risk of lone atrial fibrillation and subsequent adverse cardiac events in Chinese Han males.
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Does not support clinical genetic testing for lone AF; leaves open replication in prospective multi-ethnic cohorts.
Wang et al. (2013) conducted a case-control in Lone atrial fibrillation (n=554). ACE2 gene polymorphism rs2106809 T allele vs. Non-carriers / healthy controls was evaluated on Lone atrial fibrillation in males (OR 1.24, 95% CI 1.01-1.52, p=0.03). The rs2106809 T allele of the ACE2 gene was associated with an increased risk of lone atrial fibrillation in Chinese males (OR 1.24; 95% CI 1.01-1.52; P=0.03).
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