Key result
AGTR1 rs1492099 minor allele linked to ~73% higher risk of structural AF.
Why the study?
Are single nucleotide polymorphisms in the AGTR1 and ACE2 genes associated with structural atrial fibrillation in a Chinese Han population?
Case-Control (n=600)
No
Are single nucleotide polymorphisms in the AGTR1 and ACE2 genes associated with structural atrial fibrillation in a Chinese Han population?
Odds Ratio: 1.727 (95% CI 1.154–2.487)
Absolute Event Rate: 14.2% vs 8.8%
p-value: p=0.004
Polymorphisms in the AGTR1 and ACE2 genes are associated with an increased risk of structural atrial fibrillation in a Chinese Han population.
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May inform genetic AF risk models in Chinese Han; leaves open replication and prospective validation.
Feng et al. (2017) conducted a case-control in Structural atrial fibrillation (n=600). AGTR1 gene polymorphism rs1492099 minor allele vs. Major allele / Controls without structural AF was evaluated on Frequency of the minor allele of SNP rs1492099 in AGTR1 (OR 1.727, 95% CI 1.154-2.487, p=0.004). The minor allele of the AGTR1 gene polymorphism rs1492099 was significantly associated with an increased risk of structural atrial fibrillation in a Chinese Han population (OR 1.727).
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