Key result
The rs3789678 polymorphism in the AGT gene was significantly associated with an increased risk of nonfamilial atrial fibrillation in the Chinese Han population (OR 1.678).
Why the study?
Are polymorphisms in the renin-angiotensin-aldosterone system (RAS) genes associated with nonfamilial atrial fibrillation in the Chinese Han population?
Case-Control (n=2,321)
No
Are polymorphisms in the renin-angiotensin-aldosterone system (RAS) genes associated with nonfamilial atrial fibrillation in the Chinese Han population?
Odds Ratio: 1.678 (95% CI 1.313–2.146)
p-value: p=1.28E-03
Specific polymorphisms in the AGT gene (rs3789678 and rs11568023) are associated with altered risk of nonfamilial atrial fibrillation in the Chinese Han population.
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AGT variants may refine AF susceptibility assessment in Chinese Han adults; leaves open replication and causal validation before clinical translation.
Zhao et al. (2015) conducted a case-control in Nonfamilial Atrial Fibrillation (n=2,321). AGT gene rs3789678 polymorphism vs. Non-AF heart disease patients and healthy subjects was evaluated on Risk of nonfamilial atrial fibrillation associated with AGT rs3789678 (CT vs CC genotype) (OR 1.678, 95% CI 1.313-2.146, p=1.28E-03). The rs3789678 polymorphism in the AGT gene was significantly associated with an increased risk of nonfamilial atrial fibrillation in the Chinese Han population (OR 1.678).
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