Why the study?
Do polymorphisms in the angiotensinogen and ACE genes predict the risk of developing atrial fibrillation in the general population?
Do polymorphisms in the angiotensinogen and ACE genes predict the risk of developing atrial fibrillation in the general population?
Genetic variations in the renin-angiotensin system, specifically the angiotensinogen a-20c and ACE I/D polymorphisms, are significant predictors of incident atrial fibrillation in the general population.
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Supports RAS polymorphism inclusion in AF risk models; extends candidate-gene studies but remains hypothesis-generating without prospective validation.
Ravn et al. (2008) studied this question.
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