Key result
Visceral obesity and associated pathophysiological mechanisms, including hyperleptinemia and endothelial dysfunction, significantly contribute to the development and progression of gastroesophageal reflux disease.
Why the study?
Pathogenetic mechanisms of the combined formation of gastroesophageal reflux disease and obesity in young people, including the roles of adipose tissue hormones and nitric oxide, involve unresolved and controversial issues.
This review highlights the pathophysiological and biochemical links between GERD and obesity, particularly the influence of adipokines and endothelial dysfunction.
Supports adipokine-mediated GERD risk in obesity; leaves open whether targeted interventions modify progression.
The article analyzes the latest ideas about the pathogenetic mechanisms of the combined formation of gastroesophageal reflux disease and obesity in young people. Special attention is paid to the role of adipose tissue hormones and nitric oxide in this process. Unresolved and controversial issues to date are noted, and prospects for further research in this direction are analyzed.
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Oparin et al. (2024) conducted a review in Gastroesophageal reflux disease (GERD) and obesity. Obesity and adiposity-related factors was evaluated. Visceral obesity and associated pathophysiological mechanisms, including hyperleptinemia and endothelial dysfunction, significantly contribute to the development and progression of gastroesophageal reflux disease.
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