October 15, 1999Circulation Research

Role of Na ⁺ /H ⁺ Exchanger During Ischemia and Preconditioning in the Isolated Rat Heart

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Population

Isolated perfused rat hearts

Comparison

Preconditioning, Na+/H+ exchange inhibitor… vs 30 minutes of ischemia only

Design

Preclinical

Follow-up

30 minutes of reperfusion

Authors

XXXiaohui XiaoGuangzhou University of Chinese Medicine DADavid G. AllenUniversity of North Carolina at Chapel Hill

Discussion

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Implication

NHE inhibition may mediate preconditioning cardioprotection in rat hearts; leaves open clinical translation.

Structured PICO

Population

Isolated perfused rat hearts

Intervention

Preconditioning (3x5-minute periods of ischemia), Na+/H+ exchange inhibitor 5-(N-methyl-N-isobutyl)amiloride (MIA), or tetrodotoxin (TTX, 100 nmol/L)

Comparator

30 minutes of ischemia only

Outcome

Recovery of developed pressure (DP) on reperfusionsurrogate

Preconditioning protects against ischemia-reperfusion injury in isolated rat hearts by inhibiting the Na+/H+ exchanger during early reperfusion, preventing intracellular Na+ and Ca2+ overload.

Cite This Study

Xiao et al. (1999) studied this question.

synapsesocial.com/papers/6a2072f7cbc595e190317757 https://doi.org/10.1161/01.res.85.8.723

Topics

Women and heart disease

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Role of Na ⁺ /H ⁺ Exchanger During Ischemia and Preconditioning in the Isolated Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Role of Na ⁺ /H ⁺ Exchanger During Ischemia and Preconditioning in the Isolated Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider