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March 1, 1973Journal of Lipid ResearchOpen Access

Biosynthesis of lymph and plasma lipoprotein apoproteins by isolated perfused rat liver and intestine

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Population

Isolated perfused rat liver and intestine

Design

Preclinical

Authors

HWH.G. WindmuellerNational Institutes of HealthPHPeter N. HerbertInternational Wildlife Consultants (United Kingdom)RLRobert I. LevyGeneral / Preventive / Lipids

Discussion

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Implication

Supports plasma apoprotein transfer to intestinal VLDL in rats; leaves open human lipoprotein assembly mechanisms.

Structured PICO

P
Population
Isolated perfused rat liver and intestine
I
Intervention
Perfusion with blood containing [(3)H]lysine
O
Outcome
Incorporation of [(3)H]lysine into apoprotein bands of VLDL, LDL, and HDLsurrogate

This preclinical study demonstrates that the rat intestine does not synthesize group III apoprotein peptides, suggesting that nascent intestinal VLDL acquires these peptides from other plasma lipoproteins.

Cite This Study

Windmueller et al. (1973) studied this question.

synapsesocial.com/papers/6a2076c204d2adee4bf48cb4https://doi.org/10.1016/s0022-2275(20)36909-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fine Structure of the His Bundle1971 · 212 citations
  2. 2Fat transport and lymph and plasma lipoprotein biosynthesis by isolated intestine1972 · 99 citations
  3. 3Production of β-Lipoprotein by Intestine in the Rat1968 · 124 citations
  4. 4Effect of insulin on release of glucose and urea by isolated rat liver1963 · 144 citations
  5. 5Total Inhibition of Hepatic β-Lipoprotein Production in the Rat by Orotic Acid1967 · 166 citations