Why the study?
Do ACE inhibitors or ANG II receptor blockers reduce radiation-induced pneumonitis and fibrosis in a rat model of bone marrow transplant?
Population
Male WAG/Riji/MCV rats receiving total body irradiation and cyclophosphamide in preparation for bone marrow…
Comparison
L 158,809, Captopril, or Enalapril administered… vs Irradiated and cytoxan treated rats not…
Design
Preclinical
Follow-up
56 days post transplant
Authors
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Does not yet support clinical use in radiation pneumonitis; leaves open efficacy for preventing fibrosis in bone marrow transplant recipients.
Do ACE inhibitors or ANG II receptor blockers reduce radiation-induced pneumonitis and fibrosis in a rat model of bone marrow transplant?
ACE inhibitors and ANG II receptor blockers protect against radiation-induced pneumonitis and fibrosis in a rat model, suggesting a potential pharmacological use for these drugs in preventing idiopathic pneumonia syndrome.
Molteni et al. (2007) studied this question.
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