Why the study?
Does Angiotensin-(1-7) prevent radiation-induced fibrosis and stiffening in a mouse model of extremity sarcoma radiation therapy?
Population
Male CD-1 mice
Comparison
Continuous Angiotensin- delivery initiated three… vs Nonirradiated controls and simulated sarcoma…
Design
Preclinical, randomized to one of three treatment groups
Follow-up
up to four months
Authors
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Supports investigation of Ang-(1-7) as radioprotectant; hypothesis-generating in mouse sarcoma models, requiring clinical trials.
Does Angiotensin-(1-7) prevent radiation-induced fibrosis and stiffening in a mouse model of extremity sarcoma radiation therapy?
Angiotensin-(1-7) prevents radiation-induced fibrosis and muscle stiffening in a preclinical mouse model, suggesting potential as an adjuvant radioprotectant therapy.
Willey et al. (2016) studied this question.
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