Key result
Single-dose citrulline malate shows no effect on post-exercise nocturnal BP dipping in hypertensive adults.
Why the study?
Citrulline malate combined with exercise shows potential as an adjunct in hypertension management, but its impact on nocturnal blood pressure dipping remains unexplored.
Does a single dose of citrulline malate improve nocturnal blood pressure dipping after exercise in hypertensive adults?
RCT (n=20)
double-blind
randomly assigned
Does a single dose of citrulline malate improve nocturnal blood pressure dipping after exercise in hypertensive adults?
p-value: p=0.399
A single dose of citrulline malate prior to exercise does not alter nocturnal blood pressure dipping but may lower waking and 24-hour diastolic blood pressure in hypertensive patients.
Does not support single-dose citrulline malate for post-exercise nocturnal BP dipping in hypertension; challenges acute benefit and leaves chronic dosing open.
BACKGROUND: Citrulline malate (CM), especially when used in conjunction with physical exercise, has demonstrated potential as a non-pharmacological adjunct in the management of hypertension. Nevertheless, its impact on nocturnal blood pressure dipping remains unexplored. OBJECTIVE: Evaluate the impact of a single dose of CM on nocturnal blood pressure dipping after exercise in hypertensive individuals. METHODS: In a double-blind, placebo-controlled, parallel-group clinical trial, twenty hypertensive adults (55 ± 16 years) were randomly assigned to either a CM (6 g) or placebo (6 g of corn starch) group (PLA). Resting blood pressure was measured after a 20-min period of comfortable seating in a calm environment. Both groups underwent 40 min of treadmill running/walking at an intensity of 60-70% of their reserve heart rate, 120 min after ingesting the substances. Ambulatory blood pressure monitoring was employed to measure blood pressure over 24 h. RESULTS: = 0.399, respectively). CONCLUSIONS: The study found no significant changes in the post-exercise nocturnal blood pressure dip following a single dose of CM supplementation. However, a notable reduction in diastolic blood pressure was observed during the waking period and over the average 24-h monitoring period. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE: ClinicalTrials.gov platform (NCT03378596).
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Domingues et al. (2024) conducted an RCT in hypertension (n=20). Citrulline malate vs. placebo (6 g of corn starch) was evaluated on nocturnal blood pressure dipping after exercise (p=0.399). A single dose of citrulline malate before exercise did not significantly change post-exercise nocturnal blood pressure dipping in hypertensive adults (p=0.399).
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