Effect of PCOS on glucose metabolism

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine problems in women of reproductive age, which is multifactorial in etiology. It is associated with menstrual dysfunction and subfertility. The menstrual dysfunction that occurs with PCOS arises from anovulation or oligo-ovulation. It causes amenorrhea to oligomenorrhea. Hyperinsulinemia and insulin resistance are commonly associated with PCOS. So our study includes estimating FBS and PPBS (2 hour after OGTT) in PCOS patients to know about glucose metabolism in PCOS. Aims & Objective: To know the effect of PCOS on glucose metabolism in younger age group. Materials and Methods: A case control study was conducted in 50 PCOS patients (15 to 25 years age) and 50 normal menstruating women, matched for age and anthropometric data. Statistical analysis was done by using student t test. Results: FBS (Fasting Blood Sugar) and PPBS (Postprandial Blood Sugar) after 2 hour OGTT were significantly raised in PCOS patients compared to normal menstruating women. Conclusion: PCOS patients are more prone for impaired glucose tolerance and type 2 Diabetes Mellitus. So they should screen for impaired glucose tolerance and type 2 Diabetes Mellitus to prevent complications. [Natl J Physiol Pharm Pharmacol 2013; 3(2.000): 167-170]