Why the study?
Does polycystic ovary syndrome impair glucose effectiveness and insulin sensitivity compared to matched controls?
Population
Patients with polycystic ovary syndrome (PCOS) and age- and weight-matched control subjects
Comparison
Polycystic ovary syndrome (PCOS) vs Age- and weight-matched control subjects
Design
Case-control
Authors
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PCOS associated with reduced glucose effectiveness; leaves open independent contribution to diabetes risk pending prospective studies.
Does polycystic ovary syndrome impair glucose effectiveness and insulin sensitivity compared to matched controls?
Patients with PCOS exhibit independent alterations in both glucose- and insulin-mediated glucose uptake, similar to familial non-insulin dependent diabetes mellitus.
Falcone et al. (1992) studied this question.
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